Sickle Erythrocytes

The band 3 molecule is an anion channel for bicarbonate in the erythrocyte’s membrane that assumes a different role in senescent erythrocytes where it adopts a cluster configuration. These band 3 clusters expose previously hidden antigenic adhesive peptides which are recognized by natural band 3 antibodies that label their erythrocytes for reticuloendothelial elimination and prevent their endothelial adhesion. The sickle erythrocyte’s abnormal hemoglobin molecules cause them to experience premature senescence resulting in increased numbers of clusters, a portion of which remain uncloaked by antibodies and adhere to the vascular endothelium. The uncloaked clusters result from a deficiency of band 3 antibodies that are present in sickle cell anemia. The hypothesis presented is that the band 3 antibodies are insufficient in number to cloak all of the adhesive peptides present on cluster+ sickle erythrocytes and this is responsible for a portion of their adhesive pathology. The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information. The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.

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Last date updated on April, 2024