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Hepatology and Pancreatic Science
Open Access

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Editorial Board
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Dmitry Victorovich Garbuzenko
South Ural State Medical University
Russia

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Lorenzo Dioscoridi
Careggi Hospital of Florence
Italy

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Sarfaraz Jasdanwala
Salem Memorial Hospital in Salem
USA

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Soumil J Vyas
National University of Singapore
India

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About the Journal

Hepatic steatosis of the liver

Steatosis liver is one type of liver disease called fatty liver disease.it describes the storage of the fats in the liver .if the fats in the liver exceeds 10% then we called that as fatty liver disease. Liver normally repairs and rebuilding new liver cells when the liver cell gets damaged. If the cell gets damage repeatedly leads to cirrhosis.

Related journals of Fatty Liver

Journal of Liver, Journal of Hepatitis, Journal of Hepatology and Gastrointestinal disorders, Journal of Gastrointestinal Cancer and Stromal Tumors, Journal of Liver: Disease & Transplantation, Clinical Gastroenterology and Hepatology, Journal of Hepatology, European Journal of Surgical Oncology , Gastroenterology, Hepatology, Journal of Clinical Gastroenterology, Liver International.

Gastroenterology and Hepatology

Hepatology is a branch of medicine concerned with the study, prevention, diagnosis and management of diseases that affect the liver, gallbladder, biliary tree and pancreas. The term hepatology is derived from the Greek words “hepatikos” and “logia,” which mean liver and study, respectively.

Gastroenterology is the branch of medicine focused on the digestive system and its disorders.

Related Journals

 Journal of Hepatology and Gastrointestinal disorders, Journal of Gastrointestinal Cancer and Stromal Tumors, Gastric Cancer, Journal of Gastric Cancer.

Biliary tract

The biliary tract, (biliary tree or biliary system) refers to the liver, gall bladder and bile ducts, and how they work together to make, store and secrete bile. Bile consists of water, electrolytes, bile acids, cholesterol, phospholipids and conjugated bilirubin. Some components are synthesised by hepatocytes (liver cells), the rest are extracted from the blood by the liver.

Related Journals

Journal of Liver

Bile Acids

Bile acids are steroid acids found predominantly in the bile of mammals and other vertebrates. Different molecular forms of bile acids can be synthesized in the liver by different species.Bile acids are conjugated with taurine or glycine in the liver, forming bile salts.

Bile salts

Bile salts are a mixture of sodium salts of the bile acids and cholic and chenodeoxycholic acids synthesized in the liver as a derivative of cholesterol. Their low surface tension contributes to the emulsification of fats in the intestine and their absorption from the GI tract.

Bilirubin

Bilirubin is a yellow compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates. This catabolism is a necessary process in the body's clearance of waste products that arise from the destruction of aged red blood cells. First the hemoglobin gets stripped of the heme molecule which thereafter passes through various processes of porphyrin catabolism, depending on the part of the body in which the breakdown occurs. For example, the molecules excreted in the urine differ from those in the feces.The production of biliverdin from heme is the first major step in the catabolic pathway, after which the enzyme biliverdin reductase performs the second step, producing bilirubin from biliverdin.Bilirubin is excreted in bile and urine, and elevated levels may indicate certain diseases.

Cholesterol

Cholesterol, from the Ancient Greek chole- (bile) and stereos (solid) followed by the chemical suffix -ol for an alcohol, is an organic molecule. It is a sterol (or modified steroid),a type of lipid molecule, and is biosynthesized by all animal cells, because it is an essential structural component of all animal cell membranes; essential to maintain both membrane structural integrity and fluidity. Cholesterol enables animal cells to dispense with a cell wall (to protect membrane integrity and cell viability), thereby allowing animal cells to change shape and animals to move (unlike bacteria and plant cells, which are restricted by their cell walls).

Hepatic Duct

The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct. The duct is usually 6–8 cm length and 6mm in diameter in adults.

Hepatocytes

A hepatocyte is a cell of the main parenchymal tissue of the liver. Hepatocytes make up 70-85% of the liver's mass. These cells are involved in:

  • Protein synthesis
  • Protein storage
  • Transformation of carbohydrates
  • Synthesis of cholesterol,
  • bile salts and
  • phospholipids Detoxification, modification, and excretion of exogenous and endogenous substances
  • Initiation of formation and secretion of bile

Pancreas function and location

The pancreas is an organ located in the abdomen. It plays an essential role in converting the food we eat into fuel for the body's cells. The pancreas has two main functions: an exocrine function that helps in digestion and an endocrine function that regulates blood sugar.

Symptoms of Pancreas Diseases

Signs of chronic pancreatitis, or a damaged pancreas headed toward failure, include constant discomfort in the upper abdomen and the back, sometimes to the point of disability, explains WebMD. Weight loss from poor food absorption is another symptom, and diabetes is a possible complication.

Pancreas function in digestion

The pancreas has an endocrine function because it releases juices directly into the bloodstream, and it has an exocrine function because it releases juices into ducts. Enzymes, or digestive juices, produced by the pancreas are secreted into the small intestine to further break down food after it has left the stomach.

Pancreas removal or Pancreatectomy

In medicine, a pancreatectomy is the surgical removal of all or part of the pancreas. Several types of pancreatectomy exist, including pancreaticoduodenectomy (Whipple procedure), distal pancreatectomy, segmental pancreatectomy, and total pancreatectomy. These procedures are used in the management of several conditions involving the pancreas, such as benign pancreatic tumors, pancreatic cancer, and pancreatitis.

Pancreatic cyst

Pancreatic cysts are saclike pockets of fluid on or in your pancreas, a large organ behind the stomach that produces hormones and enzymes that help digest food. Most pancreatic cysts aren't cancerous, and many don't cause symptoms. They're typically found during imaging testing for another problem.

Laproscopic pancreatic Surgery

A distal pancreatectomy is where the bottom half of the pancreas is removed by a surgical procedure. The most frequent reason for performing a distal pancreatectomy is the presence of a tumor in the body or tail of the pancreas. After removal of the pancreas, the cut edge of the pancreas is often sutured to prevent leakage of pancreatic juice from this area. Most common complication of a distal pancreatectomy is leakage of pancreatic juice from the cut edge of the pancreas. Dilip Parekh M.D. has developed a specialized technique for suturing this part of the pancreas that has led to a very low incidence (less than 3%) of leakage of pancreatic juice after the surgery.

Tumor Pancreas

Pancreatic endocrine tumors (neuroendocrine tumors) Tumors of the endocrine pancreas are uncommon, making up less than 5% of all pancreatic cancers. As a group, they are often called pancreatic neuroendocrine tumors (NETs) or islet cell tumors. Pancreatic NETs can be benign (not cancer) or malignant

Pancreas Islets

The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (i.e., hormone-producing) cells, discovered in 1869 by German pathological anatomist Paul Langerhans.New studies show that the pancreatic islets constitute approximately 4.5% of the pancreas volume and receive 10-15% of its blood flow.The islets of Langerhans are arranged in density routes throughout the healthy human pancreas.

Pancreatic Fistula

A pancreatic fistula is an abnormal communication between the pancreas and other organs due to leakage of pancreatic secretions from damaged pancreatic ducts.

Symptoms Pancreatic Cancer

The symptoms of exocrine pancreatic cancers and pancreatic neuroendocrine tumors (NETs) are often different, so they are described separately. Having one or more of the symptoms below does not mean you have pancreatic cancer. In fact, many of these symptoms are more likely to be caused by other conditions. Still, if you have any of these symptoms, it’s important to have them checked by a doctor so that the cause can be found and treated, if needed. Early pancreatic cancers often do not cause any signs or symptoms. By the time they do cause symptoms, they have often already spread outside the pancreas.

Hepatology and Pancreatic Science is a Peer reviewed medical journal that includes a wide range of research on Hepatic diseases, associated disorders, and their treatment, pancreas and creates a platform for the authors to make their contribution towards the journal.

The editorial office promises a peer reviewing of the submitted manuscripts to maintain quality. Hepatology and Pancreatic Science is a peer reviewed journal that aims to publish the most complete and reliable source of information on the discoveries and current developments in the form of original articles, review articles, case reports, short communications, etc. in all areas of the gastroenterology, ulcerative colitis, and making them freely available worldwide. The Journal is using Editorial Manager System for online manuscript submission, review and tracking. Editorial board members of this Journal or outside experts review the manuscripts; at least two independent reviewer’s approval followed by the editor is required for the acceptance of any citable manuscript.

Special Issue

Theme: Modern approaches to the treatment of portal hypertension.

Portal hypertension is an increase in the blood pressure within a system of veins called the portal venous system. Veins coming from the stomach, intestine, spleen, and pancreas merge into theportal vein, which then branches into smaller vessels and travels through the liver. Cirrhosis of the liver is the most common cause of portal hypertension. Cirrhosis is scarring which accompanies the healing of liver injury caused by hepatitis, alcohol, or other less common causes of liver damage. In cirrhosis, the scar tissue blocks the flow of blood through the liver. Gastroesophageal variceal hemorrhage is the most dramatic and lethal complication of portal hypertension.

We are pleased to announce the invitation for the submissions on Modern approaches to the treatment of portal hypertension.

Due date of the submission: 25 January 2018

Publication date: February 2018

Submit:http://www.editorialmanager.com/clinicalgroup/  (or)  [email protected]

Guest Editor Prof. Dmitry Garbuzenko
Department of Faculty Surgery
South Ural State Medical University
Russia

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