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Pathophysiology
Pediatric Thrombocytopenia is a condition in which you have a low blood platelet count. Platelets (thrombocytes) are colorless blood cells that help blood clot. Platelets stop bleeding by clumping and forming plugs in blood vessel injuries. Thrombocytopenia often occurs as a result of a separate disorder, such as leukemia or an immune system problem.
Disease statistics
About 80% of patients without specific treatment had complete remission by six months. However, there was no large prospective study on comparing "observation" with other types of specific treatment. In the reported series, 0.9% of patients had fatal bleeding, mainly intracranial haemorrhage (ICH).
Treatment
Specific treatments for thrombocytopenia will be determined by your child’s physicians based on the cause and severity of the disease, as well as your child’s tolerance for medications, procedures and therapies. Mild cases may not require treatment and may resolve on their own. Blood transfusions with platelets or red blood cells are sometimes needed.
Research
Primary hemostasis begins when platelets adhere to the site of endothelial disruption, leading to platelet clumping. This is followed by platelet activation, which is characterized by release of granules containing von Willebrand factor, adenosine 5'-diphosphate (ADP), and serotonin.