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Adult Stills Disease

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  • Adult Stills disease

    Definition: Adult Still's disease is a rare illness which causes high fevers, rash, and joint pain. This may also lead to long-term (chronic) arthritis. Still's disease is a severe version of juvenile idiopathic arthritis (JIA), which occurs in children. Adults can have the same condition although it is much less common. It is also called adult-onset Still's disease (AOSD). Cause: The cause of adult Still's disease is unknown, but researchers are investigating the possibility that it might be triggered by some type of infection. Some people experience just one episode of adult Still's disease. In other people, the condition persists or recurs. It affects women more often than men. Pathophysiology: The cause of adult-onset Still's disease is not known, but it presumably involves interleukin-1 (IL-1), since drugs that block the action of IL-1ß are effective in treatment. Interleukin-18 is expressed at high levels

  • Adult Stills disease

    Symptoms: Joint pain, warmth, and swelling are common. Most often, several joints are involved at the same time. Often, people with the condition have morning stiffness of joints that lasts for several hours. The fever comes on quickly once per day, most commonly in the afternoon or evening. The skin rash is often salmon-pink colored and comes and goes with the fever. Symptoms also include Abdominal pain and swelling, Pain when taking a deep breath (pleurisy) and Sore throat. Treatment: Prednisone may be used for more severe cases. Medicines that suppress the immune system can also be used. Such medicines include: Methotrexate, Anakinra (interleukin-1 receptor agonist), Tocilizumab (interleukin 6 inhibitor), Tumor necrosis factor (TNF) antagonists such as Enbrel (etanercept) Drugs also Include Nonsteroidal anti-inflammatory drugs (NSAIDs), Steroids, Methotrexate, Biologic response modifiers

  • Adult Stills disease

    Statistics: The approximate Adult Stills Disease incidence in Southern Asia in India was found to be 12,990. Adult-onset Still's Disease is rare and has been described all over the world. The number of new cases of AOSD per year is estimated to be 0.16 new cases per 100,000 population. Prevalence is estimated at 1.5 cases per 100,000-1,000,000 population

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