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Ampullary cancer is a malignant tumor that arises from the Ampulla of Vater, the last centimeter of the common bile duct as it passes through the duodenum, the first section of the intestine. The diagnostic tests used to for ampullary cancer are similar to those for pancreatic cancer; endoscopy or endoscopic retrograde cholangiopancreatography (ERCP) are frequently used to make the diagnosis.A tumor blocking the Ampulla of Vater will interfere with drainage of the pancreatic and biliary secretions into the intestine.
The standard treatment for ampullary cancer is a pylorus preserving Whipple operation.Five year survival for ampullary tumors is excellent if the tumor does not invade the adjacent pancreas.The standard surgical approach to the treatment of ampullary carcinoma is pancreaticoduodenal resection (Whipple procedure). The procedure involves en bloc resection of the gastric antrum and duodenum; a segment of the first portion of the jejunum, gallbladder, and distal common bile duct; the head and often the neck of the pancreas; and adjacent regional lymph nodes.
In the Far East, Korea demonstrated highly significant increasing mortality trends for both sexes [men (4.8–7.8), p<0.001; women (2.5–4), p<0.01), while women in Japan showed an increasing trend that was significant (p<0.05). In France, a trend towards increasing mortality was observed among women (p<0.001). An upward mortality trend in women achieving significance was also seen in Malta, Bulgaria, Greece, and Germany (p<0.05). A decline in mortality was seen in both sexes only in Canada [men (7.5–6.4), women (5.9–5); p<0.01], while for men there was a downward trend noticeable in Ireland, Switzerland, Austria, the UK, and Poland [p<0.05].