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Hemoglobinopathies

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  • Hemoglobinopathies

    Haemoglobinopathy is a kind of genetic defect that results in abnormal structure of one of the globin chains of thehemoglobinmolecule. Hemoglobinopathies are inherited single-gene disorders; in most cases, they are inherited as autosomal co-dominant traits. Common hemoglobinopathies include sickle-cell disease. It is estimated that 7% of world's population (420 million) are carriers, with 60% of total and 70% pathological being in Africa.

  • Hemoglobinopathies

    Haemoglobin Functions :Transport of oxygen from the lungs to the tissues. This is due to the peculiar cooperation of the globin chains that allows the molecule to take in more oxygen where there is increased oxygen and to release oxygen in low concentration of oxygen.Transport of carbondioxide: from the tissue to the lungs.the end product of tissue metabolism is acidic which increases the hydrogen ion in solution. the hydrogen ion combines with bicarbonates to produce.

    Symptoms and signs: Blood tests (Findings).

  • Hemoglobinopathies

    Statistics: The age of the college students ranged from 17 to 26 years and included both males and females in the ratio of 1: 1.2. The antenatal women were in the age group of 17 to 37 years. Table 1 shows the distribution of β-thalassemia and other haemoglobinopathies detected at the six centres. In all, 56,780 individuals were screened and the overall prevalence of β-thalassemia carriers was 2.78 % (95 % CI 2.66–2.94). Ludhiana and Kolkata had the highest prevalence 3.96 %. HbE trait was highly prevalent in Dibrugarh—23.9 % (95 % CI 22.99–25.01) and was also more common in Kolkata—3.92 % (95 % CI 3.52–4.28) while few cases were also seen in the other regions.

 

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