Movement disorders are a group of diseases and syndromes affecting the ability to produce and control movement. Though it seems simple and effortless, normal movement in fact requires an astonishingly complex system of control. Movement is produced and coordinated by several interacting brain centers, including the motor cortex, the cerebellum & a group of structures in the inner portions of the brain called the basal ganglia.
A total population of 100,802 in Kolakata, India was screened. The age-adjusted prevalence rate (PR) and average annual incidence rate were 52.85/100,000 and 5.71/100,000 per year, respectively. The slum population showed significantly decreased PR with age compared with the nonslum population. The adjusted average annual mortality rate was 2.89/100,000 per year.
Tizanidine (Zanaflex) acts on the central nervous system. It does not usually cause reduced muscle strength. The most common side effect is sedation, and other side effects include low blood pressure, dry mouth, dizziness, and hallucinations. Liver problems may occur with this medication, and frequent lab tests are performed to evaluate liver function.
Transplantation of fetal cells into the basal ganglia has produced mixed results in Parkinson's disease and is being researched for application in other movement disorders.