Non-ulcer dyspepsia (NUD) is a common problem wherein patients suffer from indigestion and other symptoms suggestive of an ulcer, but no abnormality is found on investigation. Prevalence of dyspepsia was similar in men (30.9%) and women (29.7%). Dyspepsia was more prevalent in subjects aged > 40 years (35.1%, p=0.00003). Most common symptoms included abdominal fullness (n= 614, 24%), abdominal pain (n=374, 13.6%), heartburn (n=272, 10.7%) and belching (n=271,10.6%).
Treatment with medications has variable success. Some patients obtain relief from antacids or acid-suppressing drugs, and some patients with symptoms suggestive of a problem with stomach emptying may be helped by medications which increase emptying. Prokinetic agents would empirically seem to work well since delayed gastric emptying is considered a major pathophysiological mechanism in functional dyspepsia.