Rabies Virus can ready to reproduce in muscle and afterward ties to nicotinic acetylcholine receptors at neuromuscular intersection. Infection goes inside of axons in fringe nerves through retrograde quick axonal transport and Replication in engine neurons in spinal string and neighborhood dorsal root ganglia and fast rising to cerebrum. The primary tainted regions at mind neurons with neuronal brokenness.
In India, mostly it is like complete pre-exposure series consists of three doses of vaccine injected into the deltoid muscle on days 0, 7, and 21 or 28. The vaccines used for pre-exposure and post-exposure vaccination are the same, but the immunization pattern is different. Even when pre-exposure vaccine has been received, urgent medical advice should be sought after any animal or bat bite.
In India the statistical rate is about 99% as it has highest incidence of rabies globally. India is reported to have the highest incidence of rabies globally. A multicenter study in 2003 showed that 20 565 human deaths occur annually and a large-scale verbal autopsy study in 2005 put the figure conservatively at 12 700, without adjustment for atypical cases not captured by this latter method