alexa X-linked agammaglobulinemia | India| PDF | PPT| Case Reports | Symptoms | Treatment

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X-linked Agammaglobulinemia

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  • X-linked agammaglobulinemia


    X-linked agammaglobulinemia (XLA), or Bruton agammaglobulinemia, is an inherited immunodeficiency disease caused by mutations in the gene coding for Bruton tyrosine kinase (BTK). BTK is critical to the maturation of pre B cells to differentiating mature B cells.

  • X-linked agammaglobulinemia

    Treatment of X-linked agammaglobulinemia

    No curative therapy exists for X-linked agammaglobulinemia (XLA), or Bruton agammaglobulinemia. Treatment for XLA is IVIG. Typical doses are 400-600 mg/kg/mo given every 3-4 weeks. Doses and intervals can be adjusted based on individual clinical responses. Therapy should begin at age 10-12 weeks. Maintenance of an IgG trough level of 500-800 mg/dL is recommended. Therapy should be started at age 10-12 weeks. Currently, no evidence supports that one particular brand or route of administration (IV vs SC) is better than the other

  • X-linked agammaglobulinemia

    Major Research on X-linked agammaglobulinemia in India

    The research being carried out throughout the country can be stated as The authors report a series of seven cases of X-linked Agammaglobulinemia, diagnosed and receiving treatment at a tertiary care centre in Mumbai. The ages of the patients ranged from 15 mo to 15 y. After diagnosis at a mean age of 3, all were advised intravenous immunoglobulin (IvIg) infusion therapy in doses of 400-600 mg/kg every 3-4 wk.

  • X-linked agammaglobulinemia

    Disease Statistics of X-linked agammaglobulinemia

    The disease statistics can be observed as 10,650 of the total population are prone to the disease.


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