Three myelin major inhibitors, including NogoA, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glyco- protein, play an important role in limiting axonal regeneration by interacting with Nogo receptor NgR (now also termed NgR1). NgR appear to be expressed in neuron and certain non-neuronal cells,including oligodentrocytes and mcrophage. There is evidence that NgR has been shown to be involed in migration and adhesion for olfactory ensheathing cells (OECs). When NgR was released from the OECs surface with phosphatidylinositolspecific phospholipase- C or neutralized by NgR antibody, the effect of Nogo-66 on OEC adhesion and migration was markedly attenuated in vitro.
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Last date updated on September, 2014