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Factor V Leiden

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  • Factor V Leiden

    Factor V Leiden is a blood clotting disorder. It is not a disease. Factor V is a protein that is needed for blood to clot properly. Some people do not have the normal Factor V protein. Instead, they have an different form called Factor V Leiden. This is caused by a change (mutation) in the gene for this protein. The different gene that makes the Factor V Leiden protein is inherited from one or both parents.The Factor V Leiden protein is harder to “turn off” than the normal Factor V protein. This makes blood clots more likely to form, a condition called thrombophilia.Most people who have factor V Leiden never develop signs or symptoms. The first indication that you have the disorder may be the development of a blood clot (thrombosis). Deep vein thrombosis may not cause any symptoms.

  • Factor V Leiden

    If signs and symptoms do occur, they commonly affect your legs, including swelling of your ankles and feet. Other signs and symptoms may include:

    • Pain

    • Significant swelling

    • Redness 

  • Factor V Leiden

    Warmth A blood test (called a screening test) can show if one have Activated Protein C resistance. Another blood test that examines your genes (called DNA) will be done to find out if Factor V Leiden is the cause of the resistance and what type of Factor V Leiden you have. Some hospitals do only the DNA test and not the screening test. Having Factor V Leiden means that you have a greater chance of developing a dangerous blood clot in your legs (DVT) or lungs (PE). About 1 out of 10,000 people will develop a DVT or PE each year.

  • Factor V Leiden

    The risk increases with age:

    • small children have a risk of 1 in 100,000 per year

    • those in their twenties have a risk of 1 in 10,000 per year

    • by age 40, this risk is 1 in 1,000 per year

    • by age 80, this risk is 1 in 100 per year 

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