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Multidrug-Resistant TB

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  • Multidrug-Resistant TB

    Pathophysiology: TB is the world's leading cause of death from a single infectious organism, killing 2 million people each year. The TB crisis has intensified because multidrug-resistant (MDR) microbes have emerged. An incurable form of the disease may develop from infections caused by these organisms. WHO estimates more than 50 million people worldwide may be infected with MDR strains of TB.

  • Multidrug-Resistant TB

    Statistics: TB is the world's leading cause of death from a single infectious organism, killing 2 million people each year. The TB crisis has intensified because multidrug-resistant (MDR) microbes have emerged. An incurable form of the disease may develop from infections caused by these organisms. WHO estimates more than 50 million people worldwide may be infected with MDR strains of TB.

  • Multidrug-Resistant TB

    Treatment: The treatment and prognosis of MDR-TB are much more akin to those for cancer than to those for infection. Treatment of MDR-TB must be done on the basis of sensitivity testing: it is impossible to treat such patients without this information. When treating a patient with suspected MDR-TB, pending the result of laboratory sensitivity testing the patient should be started on SHREZ (Streptomycin+isonicotinyl Hydrazine+Rifampicin+Ethambutol+pyraZinamide)+moxifloxacin+cycloserine.

  • Multidrug-Resistant TB

    Major Research: The BCG vaccine has limitations, and research to develop new TB vaccines is ongoing. A number of potential candidates are currently in phase I and II clinical trials. Two main approaches are being used to attempt to improve the efficacy of available vaccines. One approach involves adding a subunit vaccine to BCG, while the other strategy is attempting to create new and better live vaccines.

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