Naegleria infection causes a disease called primary amebic meningoencephalitis This disease causes brain inflammation and destruction of brain tissue. Naegleria fowleri is a species of the genus Naegleria, belonging to the phylum Percolozoa. It is a free-living, bacteria-feeding amoeba that can be pathogenic, causing a fulminant brain infection called naegleriasis.
Though isolation of N fowleri from the nares of asymptomatic individuals has been reported, PAM itself is rare in the United States. From 1962 to 2012, 160 cases have been reported from the in India. On an average, 0- 6human infections occur every year. with death occurring within 4-6 days. Of all the 128 cases of PAM reported only few survived.
Naegleria species are highly sensitive to the antifungal drug amphotericin B, and it has been used as the core antimicrobial in virtually all cases in which recovery occurred.The medicine, when taken with other medications and along with aggressive management of brain swelling, may show promise for improved survival. The macrolide antibiotic azithromycin is effective.