Non Alcoholic Fatty Liver Disease often has no symptoms. When symptoms occur, they may include fatigue, weakness, weight loss, loss of appetite, nausea, abdominal pain, spider-like blood vessels, yellowing of the skin and eyes (jaundice), itching, fluid build up and swelling of the legs (edema) and abdomen (ascites), and mental confusion.Overall prevalence of NAFLD was 32% (173/541 subjects) (men: 35.1%, women:29.1%, p =0.140). Prevalence of most cardio-metabolic risk factors was significantly higher in NAFLD subjects. Prevalence of NAFLD (54.5%) was higher in subjects with DM compared to those with prediabetes.
Non-invasive diagnostic tests have been developed, such as FibroTest, that estimates liver fibrosis, and SteatoTest, that estimates steatosis, however their use has not been widely adopted. Apoptosis has been indicated as a potential mechanism of hepatocyte injury as caspase-cleaved cytokeratin 18 (M30-Apoptosense ELISA) in serum/plasma is often elevated in patients with NASH. Research is ongoing on many aspects of NAFLD, including pathophysiology and potential treatments. Additionally, multi-center pediatric trials are ongoing at the hospital, as part of the National Institutes of Health Non-Alcoholic Steatohepatitis Clinical Research Network.