Odontogenic infections are usually attributed to the endogenous flora of the mouth, and not to the introduction of non-resident bacteria. An important feature of suppurative odontogenic infections is that they are typically polymicrobial in nature, with mixed aerobic and anaerobic bacteria present. Most acute orofacial infections are of odontogenic origin. In normal hosts, however, they usually do not occur without some type of predisposing condition. Early recognition and management of acute orofacial infections is critical, because rapid systemic involvement can occur, especially in children. Antimicrobial therapy has an essential role in the management of these infections. The most frequent tumor was ameloblastoma (39.6%), followed by odontoma (20.1%) and the newly included keratocystic OT (13.8%) in Ireland.