Primary sclerosing cholangitis | Ireland| PDF | PPT| Case Reports | Symptoms | Treatment

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Primary Sclerosing Cholangitis

  • Primary sclerosing cholangitis

     Disease pathophysiology: 

    Primary sclerosing cholangitis which primarily causes inflammation scars within the bile ducts. These scars make the ducts hard, narrow and gradually cause serious damage to the liver. In the initial stages of disease fatigue, severe itching on various body parts, later the bilirubin levels in the body increases leading to Yellow eyes and skin (jaundice). Enlarged liver, Fever, pain in the upper right part of the abdomen. 

  • Primary sclerosing cholangitis

    Disease statistics:

    The prevalence of PSC is estimated to be 6.3 cases per 100,000 population. Western Europe is thought to have approximately the same prevalence as in the United States, though Scandinavian countries report a somewhat higher rate. In many developing countries with limited access to advanced health care, the prevalence of PSC is probably underestimated.

  • Primary sclerosing cholangitis

     Disease treatment:

    PSC carries an estimated median liver transplant-free survival time (from diagnosis) of approximately 15 years. Various models have been developed to help predict survival, but their use is generally best suited for research and not clinical purposes. Recently, normalization of serum alkaline phosphatase has been shown to be an accurate and non-invasive predictor of favorable long-term outcomes.

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