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Sclerosing Mesenteritis

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  • Sclerosing mesenteritis

    Sclerosing mesenteritis is an uncommon idiopathic disorder characterised by chronic non-specific inflammation involving the adipose tissue of the bowel mesentery.Sclerosing mesenteritis occurs when the tissue mesentery that holds the small intestines in place becomes inflamed and forms scar tissue.Sclerosing mesenteritis can cause abdominal pain, bloating and diarrhea. In rare cases, scar tissue formed by sclerosing mesenteritis can block food from moving through your digestive tract. Surgery may be necessary in this situation.

  • Sclerosing mesenteritis

    Symptoms:

    Sclerosing mesenteritis is itself non-neoplastic, but it is often associated with an underlying malignancy.  sclerosing mesenteritis is asymptomatic, gastrointestinal symptoms such as abdominal pain, nausea/vomiting, bloating, loss of appetite, weight loss and diarrhea or constipation, Occasionally, intermittent partial bowel obstruction is encountered. Non-gastrointestinal symptoms include fatigue, weight loss, night sweats and fever.

  • Sclerosing mesenteritis

    Pathophysiology:
    Sclerosing mesenteritis is chronic inflammation and fibrosis of the mesentery of unknown etiology. Fewer than 200 cases have been reported in the literature, although this is in part due to the plethora of names given to this poorly understood disease; such nomenclature includes mesenteric lipodystrophy, mesenteric panniculitis, and idiopathic primary inflammation and fibrosis of the mesentery. The disease includes three stages. Stage-1: mesenteric lipodystrophy, degeneration of mesenteric fat. Stage-2: mesenteric panniculitis, inflammatory reaction. Stage-3: retractile mesenteritis / sclerosing mesenteritis, fibrosis, which may be associated with distortion or lymphatic obstruction.

 

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