Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. The majority of cases occur in people with underlying illnesses such as tuberculosis or chronic obstructive pulmonary disease. Invasive pulmonary aspergillosis — the most severe form — occurs when the infection spreads rapidly from the lungs to your brain, heart, kidneys or skin.
This occurs only in people whose immune system is weakened, commonly from chemotherapy. Untreated, this form of aspergilla disease is usually fatal. Invasive aspergillosis can cause: Fever and chills, Cough that brings up blood-streaked sputum (hemoptysis), Severe bleeding from your lungs, Shortness of breath, Chest or joint pain.The current medical treatments for aggressive invasive Aspergillosis include voriconazole and liposomal amphotericin B in combination with surgical debridement.
For the less aggressive allergic bronchopulmonary aspergillosis findings suggest the use of oral steroids for a prolonged period of time, preferably for 6–9 months in allergic aspergillosis of the lungs. Itraconazole is given with the steroids, as it is considered to have a "steroid sparing" effect, causing the steroids to be more effective, allowing a lower dose. The approximate disease Aspergillous Incidence in country Israel in Middle East was found to be 61