Pathophysiology: A soft-tissue sarcoma is a form of sarcoma that develops in connective tissue, though the term is sometimes applied to elements of the soft tissue that are not currently considered connective tissue.
Symptoms: In their early stages, soft-tissue sarcomas usually do not cause symptoms. Because soft tissue is relatively elastic, tumors can grow rather large, pushing aside normal tissue, before they are felt or cause any problems. The first noticeable symptom is usually a painless lump or swelling. As the tumor grows, it may cause other symptoms, such as pain or soreness, as it presses against nearby nerves and muscles.
Treatment: The stage of the sarcoma is based on the size and grade of the tumor, and whether the cancer has spread to the lymph nodes or other parts of the body (metastasized). Treatment options for soft-tissue sarcomas include surgery, radiation therapy, and chemotherapy. Surgery is the most common treatment for soft-tissue sarcomas. It is important to obtain a margin free of tumor to decrease the likelihood of local recurrence and give the best chance for eradication of the tumor.
Statistics: A retrospective search of 1350 adult STS patient files that were recorded between 1995 and 2005.Overall, 134 patients 64 women (47.8%); 70 (52.2%) men, of a total of 1350 patients diagnosed with STS were also diagnosed with at least one additional primary malignancy (9.92%). Of the 64 females with STS and an additional malignancy, 27 (27/64 42%) had breast carcinoma, before or after the diagnosis of STS. All the patients were white Jewish (Ashkenazi or Sephardic) in origin. T