Pathophysiology: Hepatitis refers to an inflammatory disease which is fairly common and mainly affects the liver. Viral hepatitis is classified as A, B, C, D, E and G. All types of hepatitis viruses cause similar kind of liver damage. Inflammation happens throughout whole liver and hepatocytes are destroyed by cytotoxic cytokines and natural killer cells being part of inflammatory process. Cellular necrosis takes place but liver usually able to repair itself and regain complete function if no other complications occur.
Disease Statistics: The vaccination of infants infected with Hepatitis A has considerably reduced its prevalence. Prevalence of HDV is very low in Israel. Prevalence of chronic HBV infection in individuals in Israel is also very less.
Treatment: Intravenous rehydration is given as supportive care but no specific emergency treatment is recommended as such. Patients are admitted in conditions of severe complications. Evaluation for hepatic encephalopathy is done. Certain patients may benefit from pharmacologic therapy. Patients are advised to avoid prolonged or vigorous physical exertion until their symptoms improve and maintain adequate hydration.
Research: Studies are majorly focussed in the treatments and cure of HBV and HCV. One of major centre in the nation includes Department of Community Medicine and Epidemiology Carmel Medical Center, Technion Haifa.