Ataxia is typically defined as the presence of abnormal, uncoordinated movements. An unsteady, staggering gait is described as an ataxic gait because walking is uncoordinated and appears to be ‘not ordered’. Ataxia can also refer to a group of neurological disorders in which motor behavior appears uncoordinated.
Symptoms of Ataxia are Gait/Posture abnormalities, Fine motor incoordination, Speech and swallowing difficulties, Visual abnormalities, Increased fatigue, Cognitive and Mood Problems. Causes are Inherited/Genetic: Autosomal Dominant; Autosomal Recessive; X-Linked; Associated with a Mitochondrial Disorder. Acquired: Structural/Demyelinating; Toxic/Metabolic; Paraneoplastic; Infectious/Postinfectious; Autoimmune.
Therapy for ataxic patients is multi-modal. Pharmacological treatment has been beneficial in a small number of patients with specific ataxias and further research is ongoing worldwide. Examples of treatable ataxias include those due to deficiencies of vitamin E or coenzyme Q10 and Episodic Ataxia Type 2 (EA2), in which episodes of cerebellar dysfunction are reduced by acetazolamide treatment. GABAergic agents such as clonazepam, beta-blockers such as propranolol, or Primidone may reduce the prominence of some cerebellar tremors.