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Atypical Depression

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  • Atypical depression

    Definition: Any type of depression can make you feel sad and keep you from enjoying life. However, atypical depression — also called depression with atypical features — means that your depressed mood can brighten in response to positive events. Other key symptoms include increased appetite, sleeping too much, feeling that your arms or legs are heavy, and feeling rejected.

  • Atypical depression

    Symptoms: Depression that temporarily lifts in response to good news or positive events, Increased appetite that can cause weight gain, Increased desire to sleep, usually more than 10 hours a day, Heavy, leaden feeling in your arms or legs that lasts an hour or more in a day — a feeling that is different from fatigue, Sensitivity to rejection or criticism, which affects your relationships, social life or job.

  • Atypical depression

    Statistics: MDE with irritability was present in 59.7% (208/348) of BP-II and in 37.4% (95/254) of MDD (p=0.0000). In BP-II, MDE with, versus MDE without, irritability had significantly younger index age, higher rates of axis I comorbidity, atypical depressive features, and DMX. Upon logistic regression, we found a significant independent association between BP-II MDE with irritability and DMX. In UP, MDE with, versus without, irritability had significantly younger age and age at onset, higher rates of atypical depression, DMX, and bipolar family history. Logistic regression revealed a significant independent association between MDE with irritability and DMX. Given that we had excluded patients with borderline personality, the high prevalence of irritable-hostile depressives in this outpatient population means that hostility cannot be considered the signature of that personality.

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