Lichen sclerosus is an uncommon condition that creates patchy, white skin that's thinner than normal. Lichen sclerosus can affect skin anywhere on your body. But it most often involves skin of the vulva, foreskin of the penis or skin around the anus. Inflammation and altered fibroblast function in the papillary dermis leads to fibrosis of the upper dermis. Genital skin and mucosa are affected most frequently, but extragenital lichen sclerosus does occur, and even rare oral presentations are reported.
OLP may involve any site of the oral mucosa, usually bilaterally, most commonly involving the buccal mucosa, gingivae, and lateral borders of the tongue. OLP is notoriously associated with premalignant risk, and with malignant transformation rate ranging between 0.4 and 5.6%.The overall prevalence of HCV seropositivity in the Israeli population was approximately 0.5% when determined by non-confirmed enzyme-linked immunosorbent assay testing, ranging from 0.06% in native-born Israelis to 3.6% among individuals born in other countries who immigrated to Israel, mostly from the former Soviet Union.