is a disorder that damages the filters (the glomeruli) of the kidney. It is one of the most common forms of glomerular diseases (glomerulonephritis) that results in leakage by the kidney of large amounts of protein into the urine (referred to as proteinuria). Currently, the only way to diagnose the disease is through a biopsy.
When very large amounts of protein are lost in the urine, it is often called the Nephrotic Syndrome. MN was initially named for the thickened (membranous) appearance of the glomerular capillary wall by light microscopy and staged according to the growth of the and their incorporation into the expanded (GBM) as seen on EM.
In the Modification of Diet in study, patients with greater than 1 g/day had a significantly better outcome when their BP was reduced to a lower target of 125/75 mmHg, compared with those with a higher blood pressure target. The anti-proteinuric effect is generally modest (<30% decrease) and is more significant in patients with lower levels of .
Major research on disease:
Spotlight on Testing: (PLA2R) IgG Antibody: A Marker for Primary Membranous Nephropathy. Considered the human model of Heymann nephritis, which in rats is produced by antibody to megalin antigen complex on basal surface of visceral epithelial cells.