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Membranous Nephropathy

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  • Membranous nephropathy


    Membranous Nephropathy
     is a disorder that damages the filters (the glomeruli) of the kidney. It is one of the most common forms of glomerular diseases (glomerulonephritis) that results in leakage by the kidney of large amounts of protein into the urine (referred to as proteinuria). Currently, the only way to diagnose the disease is through a biopsy.

  • Membranous nephropathy

    Disease pathophysiology: 

    When very large amounts of protein are lost in the urine, it is often called the Nephrotic Syndrome. MN was initially named for the thickened (membranous) appearance of the glomerular capillary wall by light microscopy and staged according to the growth of theimmune deposits and their incorporation into the expanded glomerular basement membrane (GBM) as seen on EM.

     

  • Membranous nephropathy

    Disease statistics:

    TIN and vascular diseases were diagnosed in 1.46% and 7.78% of cases, respectively. The most common indications to perform renal biopsies were urinary abnormalities in 45.01% of cases, followed by CRF (21.51%) and NS (21.37%); macroscopic hematuria (6.41%) and ARF (5.70%) were less common. The availability of these data is diseases among patients hospitalized at the Policlinico Umberto I in Rome.

     

  • Membranous nephropathy

    Disease treatment: 

    In the Modification of Diet in Renal Diseasestudy, patients with proteinuria greater than 1 g/day had a significantly better outcome when their BP was reduced to a lower target of 125/75 mmHg, compared with those with a higher blood pressure target. The anti-proteinuric effect is generally modest (<30% decrease) and is more significant in patients with lower levels of proteinuria.

  • Membranous nephropathy

    Major research on disease:

    Spotlight on Testing: Phospholipase A2 Receptor (PLA2R) IgG Antibody: A Marker for Primary Membranous Nephropathy. Considered the human model of Heymann nephritis, which in rats is produced by antibody to megalin antigen complex on basal surface of visceral epithelial cells.

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