Multiple endocrine neoplasia(MEN-1) is also known as Wermer's syndrome. MEN-1 is a hereditory disorder .This type of hereditory disosorder generally passed from one generation to next generation. It affects the hormone producing glands.This disorder increases the development of tumors like cancerous and non cancerous tumors in glands.Non cancerous tumors may develop in parathyroid glands,Neuroendocrine system,anterior pituitory glands and skin. The symptoms are tiredness, bone pain, fractures and kidney stones, as well as stomach or intestinal ulcers.
The familial form of MEN1 syndrome occurs with a significantly higher frequency, approximately 90%, than the simplex form (only one affected individual without evidence of a positive familial history), that occurs approximately in 10% of cases. The familial form is defined as MEN1 syndrome in an individual who has either at least one first-degree relative with at least one of the main endocrine tumors or only one organ involvement and a MEN1 disease-causing germline mutation.