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Narcolepsy

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  • Narcolepsy

    PATHOPHYSILOGY Narcolepsy is a chronic disease of the central nervous system. Excessive daytime sleepiness is the main symptom and is present in 100% of patients with narcolepsy. Other primary symptoms of narcolepsy include: loss of muscle tone (cataplexy), istorted perceptions (hypnagogic hallucinations), and inability to move or talk (sleep paralysis). STATISTICS SF-36 satisfied the recommended psychometric standards. Patients with narcolepsy had all domains except Bodily Pain lower than the Italian norm. Some of the variance of Physical Functioning (R(2) 0.07), Role functioning-Physical (R(2) 0.31), General Health (R(2) 0.15), Vitality (R(2) 0.10), Social Functioning (R(2) 0.21) and Role functioning-Emotional (R(2) 0.15) was explained both by EDS (inverse correlation) and disease duration (direct correlation). TREATMENT 1.Stimulants. Drugs that stimulate the central nervous system- modafinil or armodafinil 2.Selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs)- fluoxetine 3. Tricyclic antidepressants- protriptyline, imipramine 4.Sodium oxybate MAJOR RESEARCH ON DISEASE Research needs to be focused in 2 directions: (1) prevention of lead exposure during pregnancy (2) prevention of lead leaching from bones for all women of childbearing age.

 

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