Lymphoma means a cancer of the lymphatic system. There are 2 main types of lymphoma: Hodgkin lymphoma and Non Hodgkin lymphoma .
Non-Hodgkin lymphoma, is a cancer that starts in cells called lymphocytes, which are part of the body's immune system. Lymphocytes are in the lymph nodes and other lymphoid tissues.Many different subtypes of non-Hodgkin's lymphoma exist. The most common non-Hodgkin's lymphoma subtypes include diffuse large B-cell lymphoma and follicular lymphoma. Among the 331 patients with SS studied, 9 cases of NHL occurred, while no lymphoid malignancy appeared in patients with overlapping connective tissue disease (secondary SS) or in males with primary SS. As the number of NHL cases identified on the basis of the rate in the cancer registries would have been 0.27, the RR is 33.3 (p < 0.001). The incidence rate of NHL in Italian patients with SS is about 5.1/1000 person-years. 5.4/1000 per year in the north of the country and 4.8/1000 per year in the centre-south. The relative risks are, respectively, 34.7 and 32.5.
The treatment plan depends mainly on the following:
• The type of non-Hodgkin's lymphoma
• Its stage (where the lymphoma is found)
• How quickly the cancer is growing
• The patient's age
• Whether the patient has other health problems
• If there are symptoms present such as fever and night sweat.
Other tests that may be helpful in evaluating suspected NHL include the following:
• Immunophenotypic analysis of lymph node, bone marrow, peripheral blood
• Cytogenetic studies: NHL occasionally associated with monoclonal gammopathy; possible positive Coombs test; maybe hypogammaglobulinemia