Trigeminal neuralgia (TN), also called tic douloureux, is a condition that is characterized by intermittent, shooting pain in the face.Trigeminal neuralgia affects the trigeminal nerve, one of the largest nerves in the head. The trigeminal nerve sends impulses of touch, pain, pressure, and temperature to the brain from the face, jaw, gums, forehead, and around the eyes. It has been suggested that lack of neurogenic inflammation in TGN is evidence against a major peripheral nervous system involvement. However, vasodilatation is known to occur in TGN and it normalizes when pain is controlled. Depression is often seen in patients with trigeminal neuralgia; thus, this underlying depression should be adequately treated. Tricyclic antidepressants (eg, amitriptyline, nortriptyline), as well as sodium valproate or pregabalin, have not been well studied. Amitriptyline (Elavil) can be tried, but the success rate is low. Italy people around 695,825 among the total population are suffering from this disease that is 2.68% of the population effected.