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Familial Mediterranean Fever

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  • The frequency of FMF in any location depends on the ethnic background of the population. Since the development of gene testing, which allows confirmation of FMF in some cases, the disease has been reported in unexpected locations, including by two Japanese groups. Migrations of guest workers around the world have highlighted the need for physicians to think about formerly uncommon illnesses in their home countries and the need for review articles in national journals. Approximately 5% of patients with FMF develop chronic arthritis that sometimes leads to destructive arthritis of hips or knees and may necessitate joint replacements.
  • Signs and symptoms of familial Mediterranean fever usually begin during childhood. Signs and symptoms of familial Mediterranean fever include: Fever, Abdominal pain, Chest pain, Achy, swollen joints, Constipation followed by diarrhea, A red rash on your legs, especially below your knees, Muscle aches, A swollen, tender scrotum. There's no cure for familial Mediterranean fever. However, treatment can help prevent signs and symptoms. Intake of Colchicine (This drug, taken in pill form, reduces inflammation in your body and helps prevent attacks.) Other medications include rilonacept (Arcalyst) and anakinra (Kineret).
  • Familial Mediterranean fever (FMF) is also called recurrent polyserositis. The salient features of FMF include brief recurrent episodes of peritonitis, pleuritis, and arthritis, usually with accompanying fever. Nonsense or missense mutations in the MEFV (Mediterranean fever) gene appear to cause the disease in many cases. MEFV produces a protein called pyrin (derived from the association with predominant fever) or marenostrin (derived from the phrase "our sea," because of the Mediterranean heritage of most patients). In people with familial Mediterranean fever, the gene mutation occurs in a gene called MEFV. Many different mutations in MEFV are linked to familial Mediterranean fever. Some mutations may cause very severe cases, while others may be milder.

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