Hemangioma

Hemangioma originally described any vascular tumor-like structure, whether it was present at or around birth or appeared later in life. Mulliken et al. categorized these conditions into two families: one of self-involuting tumors, growing lesions that eventually disappear, and another of malformations, enlarged or abnormal vessels present at birth and essentially permanent. The importance of this distinction is that it makes it possible for early-in-life differentiation between lesions that will resolve versus those that are permanent.

Signs and symptoms : If they are on the surface of the skin, they are reminiscent of a ripe strawberry (hence, they are sometimes referred to as "strawberry hemangiomas"). If they are just under the skin they present as a bluish swelling. Sometimes they grow in internal organs such as the liver, larynx, or small and large intestines.In most cases, hemangiomas will disappear over time. Some are formed during gestation and are called congenital hemangiomas; the most common (infantile hemangiomas) appear during the first few weeks of life.

Causes : The cause of hemangioma is currently unknown; however, several studies have suggested the importance of estrogen signaling in hemangioma proliferation. In 2007, a paper from the Stanford Children's Surgical Laboratory revealed that localized soft tissue hypoxia coupled with increased circulating estrogen after birth may be the stimulus.

Statistics: presenting 29 cases of venous malformation, 30 cases of cavernous angiomas and one case of capillary telangiectasis. We also present the data from the 763 cases of AVM obtained in the cooperative studies which were supported by the Ministry of Health and Welfare of Japan, and discussed the epidemiological and clinicopathological aspects in relation to those reported in the literature. The cooperative studies on these subjects were primarily done in conjunction with the investigation of Moya-Moya disease which is by far frequently found in Japan.