Klinefelter syndrome result from two or more X chromosome in males. Sometimes symptoms are more prominent and may include weaker muscles, greater height, poor coordination, less body hair, smaller genitals, breast growth. Klinefelter syndrome usually occurs randomly. Klinefelter syndrome is one of the most common chromosomal disorders, occurring in 1:500 to 1:1000 live male births.
An average of 86 members are effected every year in Japan. Adolescent treated with implants of controlled release testosterone, has shown good results when appropriately monitored. Hormone therapy is also useful in preventing the onset of osteoporosis. Physical therapy, speech and language therapy, counselling, and adjustments of teaching methods may be useful.