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Odontogenic infections, consisting primarily of dental caries and periodontal disease (gingivitis and periodontitis), are common and have local (eg, tooth loss) and, in some cases, systemic implications. In the United States, it is estimated that 25 percent of adults over the age of 60 have lost all their teeth (edentulism), approximately one-half from periodontal disease and one-half from dental caries. The most prevalent odontogenic cysts were radicular (72.50%), dentigerous (22.20%) and residual (4.26%) cysts in Japan.Odontogenic cysts account for 7–13% of the lesions diagnosed in the oral cavity. Most of these cysts affect adult men.
These infections are typically polymicrobial, and anaerobic bacteria are thought to play a central etiologic role. Antibiotics are an important component in the treatment of odontogenic infections. The drugs most frequently recommended are penicillin (PEN), amoxicillin-clavulanic acid (AMC), and clindamycin (CLI)—despite reports of substantial resistance to CLI among oral pathogens. Research is happening on Contiguous enlarged dental follicles with histologic features resembling the WHO type of odontogenic fibroma, Evaluation of Amelotin Expression in Benign Odontogenic Tumors.