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Primary Progressive Aphasia

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  • Primary progressive aphasia

    Disease pathophysiology:

    Primary progressive aphasia (PPA) is a type of neurological syndrome in which language capabilities slowly and progressively become impaired while other mental functions remain intact. It was first described as a distinct syndrome by M.-Marsel Mesulam in 1982. 

  • Primary progressive aphasia

     Disease statistics:

    Unlike nonfluent/agrammatic PPA, more patients with semantic PPA have had TDP-43, not abnormal tau as a dominant feature at autopsy. Some patients diagnosed with semantic PPA during life have had Alzheimer’s, not FTD changes in the brain at autopsy. The majority of semantic PPA cases are nothereditary.

  • Primary progressive aphasia

     Disease treatment:

    There is no approved treatment. But speech therapy can assist an individual with strategies to overcome difficulties. There are three very broad categories of therapy interventions for aphasia: restorative therapy approaches, compensatory therapy approaches, and social therapy approaches. Rapid and sustained improvement in speech and dementia in a patient with primary progressive aphasia.

  • Primary progressive aphasia

     Major research on disease:

    Semantic PPA is a progressive disorder of language. In later stages of the disorder, some semantic PPA patients will develop symptoms common to the other FTD subtypes, including behavioral, social or motor difficulties. The language difficulty requires education for caregivers on the misunderstood nouns and gentle distraction of the agitated uncomprehending patient. Average duration of illness is 8-10 years.

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