Rat-bite Fever | Japan| PDF | PPT| Case Reports | Symptoms | Treatment

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Rat-bite Fever

  • Rat-bite Fever
    Rat-bite fever (RBF) is an infectious disease that can be caused by two different bacteria. Streptobacillary RBF is caused by Streptobacillus moniliformis in North America while spirillary RBF or sodoku is caused by Spirillum minus and occurs mostly in Asia. Most cases of spirillary RBF occur in Japan. Rats are carriers (the reservoir) of both bacteria but rarely show signs of illness. The majority of cases are due to the rodent bite. It can also be transmitted throughout food or water that is contaminated with rat feces or urine. 


  • Rat-bite Fever

    The spirillary form causes relapsing fever, rash, and regional lymphadenitis. The condition is diagnosed by detecting the bacteria in skin, blood, joint fluid, or lymph nodes. The symptoms generally appear two weeks after infection for spirillary RBF. Treatment  of rat bite fever involves administration of amoxicillin 1 g per oral, procaine penicillin G 600,000 units IM every 12 hours, or penicillin V 500 milligrams per oral for 7 to 10 days. Erythromycin 500 milligrams might be administered to people who are allergic to penicillin.

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