"The novel discovery that co-locating amino acids are preferentially coded by co-locating (complementary) codons (in the coding nucleic acid structures, mRNA) led to the theory of mRNA chaperons. It means that mRNAs contain even folding information (in addition to the well-known sequence information) and able to guide/assist the folding of their own coded peptides as molecular chaperons. The possible mechanism of this nucleic acid assisted protein folding is modeled and illustrated in Figures 7 and 8. This initial model didnât explain the involvement and role of tRNA.
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Citation: Biro JC (2014) Suggestion to Upgrade the Canonical Concept of Translation. J Proteomics Bioinform 7: 112-120."
Last date updated on January, 2021