The case records and surgical biopsy reports of all diagnosed cases of ameloblastoma archived from January 2010 to December 2012 were retrieved from the Outpatient Department of Oral Medicine and Radiology, Vishnu Dental College, Bhimavaram, West Godavari District, Andhra Pradesh. A retrospective study of 30 cases of ameloblastoma was done, extracting parameters such as age, sex, location, radiographic findings, histopathological appearances, treatment, and recurrence from the records and comparing them with other reported studies. For analysis of the mandibular ameloblastomas, the site of occurrence was categorized into anterior (incisal-canine), body (premolar-molar region), posterior (distal to third molar), and bilateral regions (across the midline)
For the mandible, the posterior area also included the ramus, angle, coronoid process, and condyle. For the maxillary tumors, the site was subdivided into anterior (incisal-canine) and posterior (distal to canine) regions. Any tumor involving two or more sites was assigned to the region approximating the center of the lesion. Histopathology will show cells that have the tendency to move the nucleus away from the basement membrane. This process is referred to as "Reverse Polarization". While chemotherapy, radiation therapy, curettage and liquid nitrogen have been effective in some cases of ameloblastoma, surgical resection or enucleation remains the most definitive treatment for this condition.
There is evidence that suppression of matrix metalloproteinase-2 may inhibit the local invasiveness of ameloblastoma, however, this was only demonstrated in vitro. There is also some research suggesting that α5β1 integrin may participate in the local invasiveness of ameloblastomas.A recent study discovered a high frequency of BRAF V600E mutations.