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Factor V Leiden

  • Factor V Leiden

    Introduction: Factor V is an essential component in the blood coagulation cascade. Inherited or acquired deficiencies in factor V are rare causes of bleeding disorders. Factor V deficiency is also known as Owren disease. Dr. Paul Owren identified this defect in Norway in 1943. Using relatively primitive technology, he was able to deduce the existence of a fifth component required for fibrin formation, which he named factor V, thus beginning the era of Roman numerology for coagulation factors. Symptoms: Symptoms of factor V deficiency are generally very mild. Factor V levels can be as low as 10-20 percent of normal and your blood will still clot, although a bit more slowly.In cases of severe factor V deficiency, symptoms may include abnormal bleeding after giving birth, having surgery, or being injured, abnormal bleeding under the skin, umbilical cord bleeding at birth, nose bleeds, bleeding gums etc. Epidemiology: Only 150 cases of congenital factor V deficiency have been reported worldwide since 1943. Homozygous factor V deficiency is rare, occurring in approximately 1 per million population.

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