Ménière disease is a syndrome in which episodes of spinning vertigo (sense of the room spinning), hearing loss, and tinnitus(ringing in the ear)is experience .Between the unpredictable attacks, you usually do not have any problems or symptoms of the disease. The primary histopathological correlate of Meniere's disease is endolymphatic hydrops.
Paparella used the notion of a “lake, river, and pond” to explain the occurrence of malabsorption of endolymph leading to hydrops. This notion describes the endolymphatic sac as a pond, the vestibular aqueduct as a river, and the endolymphatic fluid space as a lake. When there is an obstruction near the endolymphatic sac or duct, a backlog of endolymphatic fluid is created, leading to hydrops.
The clinical response to antiviral medication indicated that vertigo due to Meniere's disease was relieved in 85–90% of patients. It is not surprising that control of vertigo was not greater than 85–90%, as mutant strains of the herpes virus group would be resistant to the acyclovir class of antivirals. Until newer antivirals are developed, approximately 10% of Meniere's disease patients with vertigo will not be controlled.
Usually, surgical treatment is only considered after all other treatments have failed to ease your symptoms. You and your doctor may decide to try a surgical or “destructive” treatment such as: Draining fluid from the inner ear Cutting the balance nerve to reduce vertigo intensity Removing the balance portion of the inner ear. This relieves the vertigo but causes complete, permanent hearing loss in the affected ear.
Major research on disease:
Developing an in-ear device that uses a programmable microfluid pump (the size of a computer chip) to precisely deliver vertigo-relieving drugs to the inner ear.Chemical labyrinthectomy with drugs injected into the inner ear to reduce balance function and risk of hearing loss.