Sclerosing mesenteritis is a rare benign process that involves inflammation, fat necrosis, and fibrosis of the mesentery. The disease poses great diagnostic challenge due to its nonspecific clinical and diagnostic findings. Includes abdominal surgery or trauma , autoimmunity , paraneoplastic syndrome, ischaemic injury and infection.small bowel mesentery is affected in most cases although the sigmoid mesocolon and omentum can also be occasionally be involved. The disease includes three stages. Stage-1: mesenteric lipodystrophy, degeneration of mesenteric fat. Stage-2: mesenteric panniculitis, inflammatory reaction. Stage-3: retractile mesenteritis / sclerosing mesenteritis, fibrosis, which may be associated with distortion or lymphatic obstruction.
Tests and procedures used to diagnose sclerosing mesenteritis include. 1. Physical exam: sclerosing mesenteritis often forms a mass in upper abdomen that can be felt during a physical exam. 2. Imaging tests: Imaging tests of your abdomen may reveal sclerosing mesenteritis. Imaging tests may include computerized tomography or magnetic resonance imaging. 3. Biopsy: Removing a sample of tissue for testing.
Glucocorticoid drugs such as prednisone, which relieve inflammation. They may be used in combination with azathioprine and colchicine.Hormonal therapy such as tamoxifen has also been shown to work. Sometimes hormonal therapy is used together with glucocorticoid drugs.Several other medications such as azathioprine, colchicine, Cyclophosphamide and thalidomide. Abdominal trauma or previous abdominal surgery could not be implicated. Our exhaustive search for malignancies or infectious diseases was negative, and the patients’ favorable response to immunosuppressive therapy belies the possibility that such diseases were undetected.