Stickler syndrome is a group of hereditary conditions characterized by a distinctive facial appearance, eye abnormalities, hearing loss, and joint problems. Robin sequence includes an opening in the roof of the mouth, a tongue that is placed further back than normal, and a small lower jaw. This combination of features can lead to feeding problems and difficulty breathing. The syndrome is thought to arise from a mutation of several collagen genes during fetal development. It is a sex independent autosomal dominant trait meaning a person with the syndrome has a 50% chance of passing it on to each child.
The incubation period of WNV ranges from 3 to 14 days. About 80% of human infections are apparently asymptomatic. Only approximately 20% of persons infected become symptomatic with a self-limited febrile illness in most cases. Symptoms of affected patients include high-grade fever, headache, myalgia, arthralgia, malaise, nausea, vomiting, skin rash, weakness, and pharyngitis. Major research is going on arthro-ophthalmopathy and genetic disorder research centers