Typhoid Fever

 Enteric fever is a more inclusive term for typhoid fever and paratyphoid fever—is a systemic infection caused by Salmonella enterica, including S enterica serotype Typhi (S typhi) and serotype Paratyphi (S paratyphi).  The incidence of typhoid fever among travellers to Mexico decreased from 0.19 to 0.13 per 100 000 between 1985 and 1994. S. typhi is spread through contaminated food, drink, or water.They travel into your intestines, and then into your blood. The bacteria travel through the blood to your lymph nodes, gallbladder, liver, spleen, and other parts of the body. 

 Historically, typhoid fever was treated with chloramphenicol, ampicillin, or trimethoprimsulfamethoxazole (co-trimoxazole), but resistance to one or two of these began to be reported.Currently, the recommendation for first-line therapy is ceftriaxone 2 g daily.41 Where isolates have been found to be fluoroquinolone sensitive, standard doses of a fluoroquinolone—eg, ciprofloxacin 500 mg twice daily may be used. Researches focusing on Antimicrobial resistance and management of invasive Salmonella disease.