To date, various nanodrug systems have been developed for different routes of administration, which include dendrimers, nanocrystals, emulsions, liposomes, solid lipid nanoparticles, micelles, and polymeric nanoparticles. Nanodrug systems have been employed to improve the efficacy, safety, physicochemical properties, and pharmacokinetic/pharmacodynamic profile of pharmaceutical substances. In particular, functionalized nanodrug systems can offer enhanced bioavailability of orally taken drugs, prolonged half-life of injected drugs (by reducing immunogenicity), and targeted delivery to specific tissues. Thus, nanodrug systems might lower the frequency of administration while providing maximized pharmacological effects and minimized systemic side effects, possibly leading to better therapeutic compliance and clinical outcomes. In spite of these attractive pharmacokinetic advantages, recent attention has been drawn to the toxic potential of nanodrugs since they often exhibit in vitro and in vivo cytotoxicity, oxidative stress, inflammation, and genotoxicity. A better understanding of the pharmacokinetic and safety characteristics of nanodrugs and the limitations of each delivery option is necessary for the further development of efficacious nanodrugs with high therapeutic potential and a wide safety margin.
Online journals follow a systematic pattern with a particular style which is universally followed to avoid confusion. All the information should be unbiased, readily proven and can be challenged in any kind of situation. Each and every fact should be made clear by providing proper evidence thereby encouraging true scholar and safeguarding copyrights. Following such stringent rules and evaluation can be costly, so publishers charge from the users who access the information, but, it will obstruct research as young researchers can afford it. Alternatively, fees can be charged from the researcher who has made the research and it can be free to the user who is interested in research thus, increasing the popularity and reputation to scholar and enhancing knowledge to user.
Last date updated on September, 2014