Paget's disease of the breast is one of the causes of chronic eczematous lesions of the nipple. It is usually associated with an underlying neoplasm which may range from a ductal carcinoma in situ to an invasive cancer. The lesion by virtue of its location poses both a diagnostic and therapeutic dilemma to the attending surgeon. The most common forms of breast cancers begin in the milk ducts, lobules or glands and are named accordingly.
Statistics of Pagets Disease of the Breast in Netherlands: The average survival rates of netherland of once in five year are 77.3%. Five to 10 percent of all women who have breast cancer have the gene mutations BRCA1 and BRCA2. If you have BRCA1 and BRCA2 mutations, your lifetime risk for developing breast cancer is between 40 percent and 85 percent. Men with these mutations are also at increased risk for developing the disease.
Treatment of paget's disease of the breast: breast-conserving surgery, followed by radiation therapy, modified radical mastectomy, axillary lymph node dissection, radiation therapy, chemotherapy, hormonal therapy, biological therapy, bisphosphonates. Moreover, the accuracy of axillary nodal staging is dependent on the number of examined lymph nodes, that is, on the quality of surgery and pathological assessment during Surgical Treastment