Poxviruses (members of the Poxviridae family) can infect both humans and animals. The orthopoxviruses include smallpox (variola), monkeypox, vaccinia, cowpox, buffalopox, cantagalo, and aracatuba viruses. The parapoxviruses include orf virus, bovine papular stomatitis virus, pseudocowpox virus, deerpox virus, and sealpox virus.Poxviruses are a group of genetically related DNA-containing viruses that have provided important scientific insights and are associated with various human diseases. Yatapoxviruses include tanapox virus and yabapoxviruses, which are found primarily in Africa. Molluscipoxviruses include the human poxvirus, molluscum contagiosum virus.Smallpox and molluscum contagiosum are specific to humans. The other viruses cause rare zoonotic infections in humans. Vaccinia virus, which has been used for vaccination, can also infect humans.