Prostate cancer is cancer that occurs in a man's prostate which is a small walnut-shaped gland that produces the seminal fluid that nourishes and transports sperm. It usually grows slowly and initially remains confined to the prostate gland, where it may not cause serious harm. While some types of prostate cancer grow slowly and may need minimal or no treatment, other types are aggressive and can spread quickly.
Symptoms: Prostate cancer may cause no signs or symptoms in its early stages but in its advanced stage symptoms can be:
Pathopysiology: Prostatic intraepithelial neoplasia (PIN) is the histologic entity widely considered to be the most likely precursor of invasive prostate cancer. Although not all patients with high-grade PIN (HGPIN) progress to develop invasive disease. It is characterized by cellular proliferation within pre-existing ducts and glands, with cytologic changes that mimic those of cancer. PIN is associated with progressive abnormalities of phenotype and genotype that are intermediate between normal prostatic epithelium and cancer. The recognition of the strong association of HGPIN and cancer has led many investigators to propose its use as an intermediate marker in chemoprevention studies.