Sclerosing mesenteritis is a rare condition of unknown cause that is characterized by chronic mesenteric inflammation . The process usually involves the mesentery of the small bowel, especially at its root, but can occasionally involve the mesocolon.
sclerosing mesenteritis is asymptomatic, gastrointestinal symptoms such as abdominal pain, nausea/vomiting, bloating, loss of appetite, weight loss and diarrhea or constipation, Occasionally, intermittent partial bowel obstruction is encountered. Non-gastrointestinal symptoms include fatigue, weight loss, night sweats and fever.
The disease stages.
Stage-1: mesenteric lipodystrophy, degeneration of mesenteric fat.
Stage-2: mesenteric panniculitis, inflammatory reaction.
Stage-3: retractile mesenteritis / sclerosing mesenteritis, fibrosis, which may be associated with distortion or lymphatic obstruction.
Various terms are used throughout the literature to describe this condition, which may lead to confusion, especially since there is a paucity of data regarding this rare disease. 12 percent of patients developed malignancy, including lymphoma, carcinoid syndrome, lung adenocarcinoma, and mesothelioma. Fulminant cases of sclerosing mesenteritis have been reported and are largely due to complications of intestinal obstruction.