Pathophysiology: Viral hemorrhagic fever (VHFs) is a general term to severe group of illness caused by RNA viruses from several viral families. It is a severe multisystem syndrome caused by infectious viruses which lead to a potentially lethal disease syndrome characterized by fever, malaise, vomiting, mucosal and gastrointestinal (GI) bleeding.VHF is caused by viruses of four families: arenaviruses, filoviruses, bunyaviruses, and flaviviruses.
Disease Statistics: In July 2008, an imported case of MHF was diagnosed in the Netherlands. The viral hemoharrgic fever response in the Netherlands was low profile and did not lead to overreacting or public alarm.
Treatment: Patients usually receive supportive therapy but as such there are no other treatment or established cure for VHFs. Ribavirin, an anti-viral drug, have been effective in treating some individuals with Lassa fever or HFRS. Treatment with convalescent-phase plasma has been used with success in some patients with Argentine hemorrhagic fever.
Research: The research study involved the resarchers from National Institute for Public Health and the Environment, Bilthoven, the Netherlands; Leiden University Medical Center, Leiden, the Netherlands; University Medical Center, Rotterdam, the Netherlands and Academic Medical Center, Amsterdam, the Netherlands supported by a grant from the Dutch Research Foundation (ZonMw).