alexa Waldenstrom Macroglobulinemia | Netherlands | PDF | PPT| Case Reports | Symptoms | Treatment

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Waldenstrom Macroglobulinemia

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  • Waldenstrom Macroglobulinemia

    Pathophysiology
    Waldenstrom macroglobulinemia (WM).could be a chronic, indolent, lymphoproliferative disorder. It Is characterised by the presence of a high level of a macroglobulin (immunoglobulin M [IgM]), elevated human body, and also the presence of a lymphoplasmacytic infiltrate within the bone marrow.

  • Waldenstrom Macroglobulinemia

    Statistics
    Between 1989 and 2007 the incidence of all non-Hodgkin lymphomas has been rising considerably from 19 to 22 per 100,000 for males and from 12 to 14 for females in The Netherlands.

  • Waldenstrom Macroglobulinemia

    Treatment
    Ought to be supported individual patient and illness characteristics (age, comorbidities,would like for fast illness management, campaign for autologous transplantation, cytopenias, IgM-related complications, hyperviscosity, neuropathy). Autologous vegetative cell transplantation is also thought of in young patients with chemosensitiveillness and in freshly diagnosed patients with very-high-risk options.

  • Waldenstrom Macroglobulinemia

    Research
    Clinical studies have shown that combining rituximab (an anti-CD20 monoclonal antibody) to standard chemotherapy regimens (cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) results in a major clinical benefit (increased response rate, and improved progression free and overall survival) in almost all subtypes of aggressive B-cell neoplasm, without relevant increase in toxicity.

 

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