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Edema is an abnormal accumulation of fluid in the interstitium, located beneath the skin and in the cavities of the body which cause severe pain. Clinically, edema manifests as swelling; the amount of interstitial fluid is determined by the balance of fluid homeostasis, and the increased secretion of fluid into the interstitium, or the impaired removal of the fluid can cause edema. Peripheral edema is edema (accumulation of fluid causing swelling) in tissues perfused by the peripheral vascular system, usually in the lower limbs. In the most dependent parts of the body (those hanging distally), it may be called dependent edema. The condition is commonly associated with aging, but can be caused by many other conditions, including congestive heart failure, trauma, alcoholism, altitude sickness, pregnancy, hypertension, sickle cell anemia, or merely long periods of time sitting or standing without moving.
Edema is swelling that is caused by fluid trapped in your body’s tissues. Edema happens most often in the feet, ankles, and legs, but can affect other parts of the body, such as the face, hands, and abdomen. It can also involve the entire body. Edema can be the result of medication, pregnancy or an underlying disease often heart failure, kidney disease or cirrhosis of the liver.